Identification product identifier methyl isocyanate other means of identification item n12440 synonyms isocyanic acid, methyl ester recommended use for laboratory use only recommended restrictions none known. This method is applicable for material containing reactive isocyanate groups. Read the use and storage of methyl isocyanate mic at bayer. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Reviewed the studies of human health effects that resulted from exposure to methyl isocyanate gas that leaked from the union carbide plant in bhopal, india, in dec. Information including publications, timelines, draft screening assements and risk management scope and submissions related to the methylenediphenyl diisocyanate and diamine mdi mda substance grouping. October 29, 2014 the dow chemical company page 4 of 7 based on the uses for mdi, the public could be exposed through.
Media in category methyl isocyanate the following 20 files are in this category, out of 20 total. Methyl isocyanate, known as mic, is a clear, colorless liquid used for the creation of pesticides. A search of the literature produced three procedures that were candidates for a validated method. This means that someone could explode the vehicle of transportation truck, train that is being used to ship the chemical, or destroy tanks that store the chemical. Methyl isocyanate substance information hazmat tool.
People exposed to high levels of methyl isocyanate in the air have experienced severe lung and eye damage. The sudden rise of pressure inside the tank forced the tanks emergency pressure release valve to open. Unreactedexcess amine is determined by backtitration with hydrochloric acid. This web page has been archived and is maintained for reference purposes only. Methyl isocyanate is not the only compound with a molecular formula of c2h3no. The statement of task calls for an examination of the use and storage of methyl isocyanate mic at the bayer cropscience facility in institute, west virginia. Program and regulatory information about this substance, including links to epa applicationssystems, statuesregulations, or other sources that track or regulate this substance. In order to ensure that chemical manufacturing takes place in a. Summary the use and storage of methyl isocyanate mic at. Methyl isocyanate an overview sciencedirect topics. In the presence of a catalyst, methyl isocyanate reacts with itself to form a cyclic trimer with no. Small amounts of methyl isocyanate may evaporate into air.
Signs and symptoms of methyl isocyanate typically include cough, dyspnea, chest pain, lacrimation, eyelid edema, and unconsciousness. Despite this low acute toxicity, an extremely low shortterm exposure limit stel of 0. Within an hour, large volumes of toxic gases, including some 30 tonnes of unreacted. Environmental protection agency office of pollution prevention and toxics 401 m street, s. Thank you for visiting our website you are exiting the department of labors web server. That year also saw the startup of a second, larger mic unit to provide for the growing demand for aldicarb and changes to carbaryl production. Get a printable copy pdf file of the complete article 1. Toxicity might develop over 1 to 4 hours after exposure. Guide for handling isocyanates safe work australia. Isocyanates occupational safety and health administration.
Methyl isocyanate is a colorless liquid that has a sharp odor. The use of hazardous chemicals such as methyl isocyanate can be a significant concern to the residents of communities adjacent to chemical facilities, but is often an integral, necessary part of the chemical manufacturing process. If a worker develops respiratory symptoms consistent with isocyanate exposure, particularly wheezing, coughing or difficulty breathing, a medical practitioner should assess the relationship. Effect of methyl isocyanate mic gas on the eyes of fischer 344 rats.
Dec 16, 2016 immediately dangerous to life or health idlh value profile, methyl isocyanate cdc pdf cas no. To receive documents or other information about occupational safety and health topics, contact. Methyl isocyanateis probably best known, or most notorious, for the deaths it caused in the worlds worst ever chemical disaster, which occurred at the union carbide works in bhopal, india. The selection of these mdimda substances for action is based on the categorization process completed in 2006 and on new information received as part of the first phase of the cmp. Methyl isocyanate reacts with water producing considerable heat plus varying amounts of the chemical products 1,3dimethylurea, some 1,3,5trimethylbiuret, and carbon dioxide. Structure, properties, spectra, suppliers and links for. Contact with the skin, eyes, and mucous membranes may result in severe irritation and permanent damage. Cdc niosh publications and products immediately dangerous. Acute exposure to methyl isocyanate may result in respiratory tract irritation, cough, chest tightness and pain, dyspnea shortness of breath, asthmatic episodes, and pulmonary edema.
Methyl isocyanate cas 624839 skin designation applies. Sds of methyl isocyanate, safety data sheets, cas 624839. Methyl isocyanate is an intermediate chemical in the production of carbamate pesticides such as carbaryl, carbofuran, methomyl, and aldicarb. Mar 03, 2011 exposure to low levels of methyl isocyanate can cause eye and throat irritation. The accidental release of methyl isocyanate gas in bhopal, india, was reported. In bhopal, india, accidental acute inhalation exposure to methyl isocyanate resulted in the deaths of about 3,800 people and adverse health effects in greater than. Unfortunately, on this fateful day the scrubbers were not working and so a deadly cloud of methyl isocyanate was released over the surrounding town. Methyl isocyanate would then be released into the air. The plant made a very effective insecticide called carbarylalso known as sevin, using a costefficient onestep process utilising the highly toxic gas, methyl isocyanate. Product safety assessment mdibased isocyanate products. Methyl isocyanate is on the hazardous substance list because it is regulated by osha and cited by acgih.
Methyl isocyanate has been found in at least 1 of the 1,585 national priorities list. Methyl isocyanate is rapidly minutes to a few hours degraded in water into other compounds. Treatment and disposal methods for waste chemicals irptc file. Identification product identifier methyl isocyanate other means of identification item n12440 synonyms isocyanic acid, methyl ester recommended use for laboratory use only. The department of labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The metric mode option can be selected in the peac tool to give temperatures in c. Ou chemical safety data no longer updated more details toxic by inhalation, lachrymator, flammable matrix scientific 038697. Persons with disabilities having difficulty accessing archived materials may contact the iris hotline for assistance. Unna datasheets display several items from the erg. Molecular weight of free methyl isocyanate and methyl isocyanateurea analyte mw free isocyanate mw derivative mi 57.
Alma detects methyl isocyanate around young sunlike stars. It affected a population of 520 000 people and it is estimated that some 20 000 people died as a result. Initially, methyl isocyanate was imported, but in 1979 a plant was added at the site for producing methyl isocyanate from phosgene and methylamine. Attach the flask to a rotary evaporator and gently evaporate to dryness under vacuum in a 65 ec water bath.
In the past there has been no validated sampling and analytical procedures for methyl isocyanate mic in air that could be used for compliance purposes. Tl 7000tl 7750 m120 or 50 basic device magnetic stirrer tm 235. The release of methyl isocyanate mic was the cause of this disaster. Exposure to methyl isocyanate typically occurs through inhalation or dermal absorption. Material safety data sheets 389 methyl isocyanate stable water, acid, alkali, amine, iron, tin, copper and their salts, other catalysts.
All structured data from the file and property namespaces is available under the creative commons cc0 license. Cdc niosh pocket guide to chemical hazards methyl isocyanate. Immediately dangerous to life or health idlh value profile. New chemicals environmental technology initiative automotive refinishing industry isocyanate profile submitted to.
This msds is the most recent received from the product manufacturer or section 12 ecological information distributor. Draw a structural isomer of methyl isocyanate that contains all closedshell atoms and formal charges of zero on each atom. The isocyanate functional group is masked through the use of a blocking agent. Read the use and storage of methyl isocyanate mic at. Uly 2015 5 guide to handling isocyanates difficulty in breathing tightness of the chest, coughing, wheezing and shortness of breath other asthmalike symptoms, and headache and discomfort.
Certain methylenediphenyl diisocyanate and diamine mdi mda substances are among those identified as priorities for action for the second phase of the chemicals management plan cmp. Apr 04, 2018 links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. If the heat is not removed quickly enough from the water reaction, the methyl isocya. The emergency response guidebook erg provides general response recommendations for first responders. Methyl isocyanate is used in the production of pesticides. Ld50s for isocyanates are typically several hundred milligrams per kilogram. Exposure to methyl isocyanate can result in cough, difficulty breathing, chest pain, excessive tearing lacrimation, swelling of the eyes, and unconsciousness. Unreactedexcess amine is determined by backtitration with. Methyl isocyanate has been found in at least 1 of the 1,585 national priorities list sites identified by the environmental protection agency epa.
Methyl isocyanate does not accumulate in the food chain. Synonyms are isocyanatomethane, methyl carbylamine and mic. The gas drifted over the densely populated neighbourhoods around the plant, killing thousands of people immediately and creating a panic as tens of thousands read more. Methyl isocyanate mic is an organic compound with the molecular formula ch3nco. Normally this would not have been too much of a problem, because any toxic gas should have been rendered harmless as it passed through sodium hydroxide scrubbers in the exhaust lines. Protocol overview methyl isocyanate, classified as a chokingpulmonary agent, is a water reactive liquid at room temperature.
Linking to a nonfederal website does not constitute an endorsement by cdc or any of its employees of the sponsors or the information and products presented on the website. Most of the methyl isocyanate released to soil will be broken down into other compounds upon contact with moisture. Mic is a lachrymatory agent, meaning it has the same effects as tear gas. The use and storage of methyl isocyanate mic at bayer cropscience the use of hazardous chemicals such as methyl isocyanate can be a significant concern to the residents of communities adjacent to chemical facilities, but is often an integral, necessary part of the chemical manufacturing process. Incineration will become easier by mixing with a more flammable solvent. Files are available under licenses specified on their description page. Science applications international corporation 11251 roger bacon drive reston, virginia 20190. Signs and symptoms of acute methyl isocyanate exposure. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. Methyl isocyanate is a colorless highly flammable liquid that evaporates quickly when exposed to the air. The facility produced the pesticide carbaryl under the trademark sevin. Since the 1984 tragedy in bhopal, india, methyl isocyanate mic has been studied extensively to provide data on its toxicity following shortterm exposures to mic vapor. Methyl isocyanate mic india environment portal news.
Workplace exposure1 there is a potential for workplace exposure to mdi in all industrial, commercial, or manufacturing settings where mdi is present. Methyl isocyanate is irritating and corrosive to the eyes, skin, and respiratory tract, including asthmalike allergy. The isocyanate is reacted with dinbutyl amine to form a urea. For more information about the substance, you may click one of the links below to take you to the relevant section. The methyl isocyanate rapidly vaporised along with products of the reaction. People working in facilities that produce or use methyl isocyanate have the highest risk of being exposed to this chemical. Search results for methyl isocyanate at sigmaaldrich. Within an hour, large volumes of toxic gases, including some 30 tonnes of unreacted methyl isocyanate, had escaped into the atmosphere. Methyl isocyanate mic is an organic compound with the molecular formula ch 3 nco. Guide to handling isocyanates table 2 isocyanate exposure to workers work activity source of exposure spraying operations e. Methyl isocyanate is used in the manufacture of pesticides, is highly toxic and is notorious due to its accidental release from a union carbide plant at bhopal in india in 1984. This iris assessment for methyl isocyanate consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions. Methyl isocyanate mic will react with water, or in the presence of catalysts such as sodium.
Exposure to low levels of methyl isocyanate can cause eye and throat irritation. Summary the use and storage of methyl isocyanate mic. Archive disclaimer this site contains archived material. This page was last edited on 31 december 2014, at 17. The use and storage of methyl isocyanate mic at bayer.
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